Applies to: Liver Disease. Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after surgery. Promethazine is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections. This medicine can cause drowsiness and may impair your mental and physical abilities to drive, operate heavy machinery, or perform other similar tasks Promethazine may cause breathing to slow or stop, and may cause death in children. It. Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, colloidal silicon dioxide, white wax, hard fat, and glyceryl monostearate. Do NOT use it to treat or manage an actual overdose. Promethazine may also be used for purposes not listed in this medication guide Promethazine. Children with Reye's syndrome or liver disease should not take Phenergan. Clinically apparent liver injury from brompheniramine or chlorpheniramine must be exceeding rare, if it occurs at all Promethazine is a first-generation antihistamine. It is important to know that the drug can cause potentially fatal slow or irregular breathing, increase the risk of seizures, and cause a life-threatening condition called neuroleptic malignant syndrome Ondansetron is an anti-nausea medication used to prevent nausea and vomiting caused by cancer chemotherapy.It is also used to prevent vomiting and nausea after surgery. Selected from data included with permission and copyrighted by First Databank, Inc. Despite its phenothiazine structure, promethazine has not been linked to instances of clinically apparent acute liver injury Promethazine. Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, colloidal silicon dioxide, white wax, hard fat, and glyceryl monostearate. nuclearpowerpants. Avoid use of promethazine in children with liver disease (including possible Reye's syndrome). It blocks the effects of the naturally occurring chemical histamine in your body Codeine on its own isn’t bad for your liver, but when it’s used in combination with other medications, it can be. It is also used to treat allergy symptoms such as rash, itching, and runny nose Avoid use of promethazine in children with liver disease (including possible Reye's syndrome). Medications known as CYP 2D6 or 2B6 inhibitors slow down the activity of this enzyme, causing an increase in the level of Phenergan in the blood. Promethazine is a phenothiazine derivative first-generation H 1 receptor antagonist but is also an antagonist at muscarinic (M 1) and dopamine (D 2) receptors.Adverse effects associated with therapeutic phenergan liver use of promethazine include dystonic reactions, psychosis in the absence of other anticholinergic symptoms or signs, and. Sleep apnea, history of—Promethazine should NOT be used in patients with any of these conditions. PHENERGAN™ (promethazine hydrochloride) Suppositories, USPDESCRIPTION. Liver function test abnormal is found, especially for people who are female, 50-59 old, have been taking the drug for < 1 month, also take medication Zofran, and have Pain Promethazine is first generation antihistamine that belongs to the phenothiazine class and is used predominantly as an antiemetic to treat nausea and vomiting and prevent motion sickness. Genetic Implication.. This medication can cause severe tissue damage, possibly requiring surgery. It is not known whether promethazine will harm an unborn baby Promethazine is a first-generation antihistamine. Lineweaver-Burk plots for the hydroxylation, S-oxidation and N-demethylation indicated that the hydroxylation occurred with a low K(m) value in human liver. Chemotherapy drugs increase secretion of serotonin, which stimulates serotonin (5-HT3) receptors in the brain, causing nausea and vomiting. It may also be used for sedating people who are agitated or anxious. Before starting Phenergan, warnings and precautions for the medication should be reviewed with your healthcare provider. Other drugs that have the same active ingredients (e.g. In addition, promethazine hydrochloride also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone Promethazine is a medicine used to treat nausea and vomiting. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain Promethazine is extensively metabolized in the liver.